Angiogenin ameliorates corneal opacity and neovascularization via regulating immune response in corneal fibroblasts

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Angiogenin ameliorates corneal opacity and neovascularization via regulating immune response in corneal fibroblasts

BACKGROUND Angiogenin (ANG), a component of tears, is involved in the innate immune system and is related with inflammatory disease. We investigated whether ANG has an immune modulatory function in human corneal fibroblasts (HCFs). METHODS HCFs were cultured from excised corneal tissues. The gene or protein expression levels of interleukin (IL)-1beta (β), IL-4, IL-6, IL-8, IL-10, complements,...

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Infantile Glaucoma and Corneal Opacity

CASE PRESENTATION A 2-day-old Hispanic female was referred to us by her pediatrician for an evaluation of her hazy corneas and to rule out glaucoma. The patient was born by uncomplicated cesarean section at 37 weeks, at which time she weighed 7 pounds, 4 ounces. There were no exposures or complications during pregnancy, and the patient had no family history of childhood ocular problems. Upon in...

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Corneal neovascularization and biological therapy

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ژورنال

عنوان ژورنال: BMC Ophthalmology

سال: 2016

ISSN: 1471-2415

DOI: 10.1186/s12886-016-0235-z